John S. McCain, the proud naval aviator who climbed from depths of despair as a prisoner of war in Vietnam to pinnacles of power as a Republican congressman and senator from Arizona and a two-time contender for the presidency, died on Saturday at his home in Arizona. He was 81.

According to a statement from his office, Mr. McCain died at 4:28 p.m. He had suffered from a malignant brain tumor, called a glioblastoma, for which he had been treated periodically with radiation and chemotherapy since its discovery in 2017.

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